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lewehu

黃莉文 助理教授

學歷

  • 高雄醫學大學醫學研究所博士
  • 高雄醫學大學醫學研究所碩士
  • 高雄醫學院醫學技術學系學士

經歷

  • 高雄醫學大學醫學檢驗生物技術學系助理教授
  • 高雄醫學大學醫學技術學系講師

研究興趣

  • 藉由arginase單株抗體之製備成央A祈盼日後在臨床應用方面以及機轉調控方面能有所貢獻。
  • 臨床應用方面:目前發現多種癌症、不孕症、嚴重精神疾病…等病人血清arginase濃度均呈上升現象,希望透過進一步之研究,能將本人研發出之ELISA偵測系統,實際應用於癌症病人之預後復發追蹤、癌症危險群人口之實驗室篩選、以及鑑別腫瘤是良性或惡性﹖這部分計畫已與臨床醫師研究合作進行中。
  • 高雄醫學機轉調控方面: arginine是NOS和arginase兩種酵素的共同基質,其中NO是一把雙刃的利劍,在人體生理病理上之研究已十分透澈,惟NOS與arginase兩者之間是如何調控﹖仍未十分清楚。因此本人預計以homocysteine對人類血管內皮細胞之傷害為研究主軸,深入探討NOS和arginase在此際所扮演的角色。

論文著作(*corresponding author)

Journal articles

  1. Hu Y.C., Hsieh B.S., Cheng H.L., Huang L.W., Huang T.C., Huang I Y., *Chang K.L. (2013) Osteoblasts survive the arsenic trioxide treatment by activation of ATM-mediated pathway. Biochemical Pharmacology 85:1018-1026 (SCI: impact factor: 4.650; Journal Rank in Categories: Pharmacology & Pharmacy 25/256=9.8 %)
  2. Chang K.L., Hu Y.C., Hsieh B.S., Cheng H.L., Hsu H.W., Huang L.W., *Su S.J. (2013) Combined effect of soy isoflavones and vitamin D3 on bone loss in ovariectomized rats. Nutrition 29:250-257 (SCI: impact factor: 3.046; Journal Rank in Categories: Nutrition & Dietetics 25/79=31.6 %)
  3. Hu Y.C., Cheng H.L., Hsieh B.S., Huang L.W., Huang T.C., *Chang K.L. (2012) Arsenic trioxide affects bone remodeling by effects on osteoblast differentiation and function. Bone 50:1406-1415 (SCI: impact factor: 4.461; Journal Rank in Categories: Endocrinology & Metabolism 26/124=21.0 %)
  4. Huang L.W., Hsieh B.S., Cheng H.L., Hu Y.C., Chang W.T., *Chang K.L. (2012) Arecoline decreases interleukin-6 production and induces apoptosis and cell cycle arrest in human basal cell carcinoma cells. Toxicology and Applied Pharmacology 258: 199-207. (SCI: impact factor: 3.630; Journal Rank in Categories: Toxicology 16/87=18.4 %)
  5. Hsieh B.S., Huang L.W., Su S.J., Cheng H.L., Hu Y.C., Hung T.C., *Chang K.L. (2011) Combined arginine and ascorbic acid treatment induces apoptosis in the hepatoma cell line HA22T/VGH and changes in redox status involving the pentose phosphate pathway and reactive oxygen and nitrogen species. Journal of Nutritional Biochemistry 22: 234-241. (SCI: impact factor: 4.592; Journal Rank in Categories: Nutrition & Dietetics 9/79=11.4 %)
  6. Hung T.C., Huang L.W., Su S.J., Hsieh B.S., Cheng H.L., Hu Y.C., Chen Y.H., Hwang C.C., *Chang K.L. (2011) Hemeoxygenase-1 expression in response to arecoline-induced oxidative stress in human umbilical vein endothelial cell. International Journal of Cardiology 151: 187-194. (SCI: impact factor: 6.175; Journal Rank in Categories: Cardiac & Cardiovascular system 11/125=8.8 %)
  7. Cheng H.L., Su S.J., Huang L.W., Hsieh B.S., Hu Y.C., Hung T.C., *Chang K.L. (2010) Arecoline induces HA22T/VGH hepatoma cells to undergo anoikis - involvement of STAT3 and RhoA activation. Molecular Cancer 9: 126. (SCI: impact factor: 5.397.; Journal Rank in Categories: Oncology 29/203=14.3 %)
  8. Chang K.L., Cheng H.L., Huang L.W., Hsieh B.S., Hu Y.C., Chih T.T., Shyu H.W., *Su S.J. (2009) Combined effects of terazosin and genistein on a metastatic hormone-independent human prostate cancer cell line. Cancer Letters 276: 14-20. (SCI: impact factor: 5.016; Journal Rank in Categories: Oncology 33/203=16.3 %)

Conference papers

  1. Cheng H.L., Hsieh B.S., Hu Y.C., Huang T.C., Huang L.W., *Chang K.L. (2013) The molecular mechanisms of arecoline-induced cell detachment in HA22T/VGH hepatoma cells. The Taiwan Society for Biochemistry and Molecular Biology Winter Camp. (Poster) (Taichung, Taiwan)
  2. Hu Y.C., Cheng H.L., Hsieh B.S., Huang L.W., Huang T.C., Huang I.Y., *Chang K.L. (2013) The anti-apoptotic capacity of osteoblasts in prevention for arsenic trioxide damage. The Taiwan Society for Biochemistry and Molecular Biology Winter Camp. (Poster) (Taichung, Taiwan )
  3. Cheng H.L., Hsieh B.S., Hu Y.C., Huang T.C., Huang L.W., *Chang K.L. (2013) The effects of arecoline on IL-6/IL-6 receptor signaling in hepatoma cells. The Twentieth-Eighth Joint Annual Conference of Biomedical Sciences. (Poster) (Taipei, Taiwan)
  4. Hu Y.C., Cheng H.L., Hsieh B.S., Huang L.W., Huang T.C., Huang I.Y., *Chang K.L. (2013) Osteoblasts survive the arsenic trioxide treatment by activation of ATM-mediated pathway. The Twentieth-Eighth Joint Annual Conference of Biomedical Sciences. (Poster) (Taipei, Taiwan)
  5. Hu Y.C., Cheng H.L., Hsieh B.S., Huang L.W., Huang T.C., *Chang K.L. (2012) Arsenic trioxide affects bone remodeling by effects on osteoblast differentiation and function. The Twentieth-Seventh Joint Annual Conference of Biomedical Sciences. (Poster) (Taipei, Taiwan)
  6. Hsieh B.S., Cheng H.L., Hu Y.C., Huang T.C., Huang L.W., *Chang K.L. (2012) Glutathione depletion increases apoptosis of hepatoma cells-treated with combination of arginine and ascorbic acid. The Twentieth-Seventh Joint Annual Conference of Biomedical Sciences. (Poster) (Taipei, Taiwan)
  7. Cheng H.L., Hsieh B.S., Hu Y.C., Chang W.T., Huang T.C., Huang L.W., *Chang K.L. (2012) Arecoline decreases interleukin-6 production and induces apoptosis and cell cycle arrest in human basal cell carcinoma cells. The Twentieth-Seventh Joint Annual Conference of Biomedical Sciences. (Poster) (Taipei, Taiwan)
  8. Hsieh B.S., Cheng H.L., Hu Y.C., Huang L.W., *Chang K.L. (2011) Combined arginine and ascorbic acid treatment induces apoptosis in the hepatoma cell line HA22T/VGH and changes in redox status involving the pentose phosphate pathway and reactive oxygen and nitrogen species. The Twentieth-Sixth Joint Annual Conference of Biomedical Sciences. (Taipei, Taiwan)

簡介

  • 1966年水瓶座、喜愛百科全書、藝術家作品全集…etc) 及思考。
  • 基於出身於醫技系、且任教於醫技系,因此將改造醫技系畢業生前途視為己任,加上身為血液學教師,不忍看技三學生百般苦讀猶不得其門而入,於是歷經數年之研發,已自創出一套獨特血液學教法,不僅上課生動活潑、更讓醫技學生對臨床醫檢師有強烈認同感、同時亦可啟發學生往生物科技職場奮鬥的方向感。
  • 若您有興趣,歡迎e-mail: lewehu@cc.kmu.edu.tw或是瀏覽我的個人網站http://huang.dlearn.kmu.edu.tw喲!

 

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